目的分析肥胖儿童糖脂代谢的临床特征并分析膳食纤维联合运动干预对患儿的临床效果,为进一步了解学龄期肥胖儿童体内糖脂代谢紊乱情况,及早给予干涉,降低成年及老年慢性疾病的风险。方法选取2013年6月-2014年11月在青海省儿童医院园诊断为肥胖的110例儿童为肥胖组,同期通过自愿原则在当地筛选出90名体检正常的儿童为正常组,收集两组身高、体重、腰围、臀围数据,并计算体质指数(BMI),比较这些简单人体测量数据的差异。同时将肥胖组儿童随机分为两组:试验组(55例)和对照组(55例),试验组采用膳食纤维饮食联合运动干预,对照组不采取特殊的干预措施,比较两组患儿治疗5周前后反映糖代谢、脂代谢血液中生化指标、血压的变化情况。结果与正常组比较,肥胖组的腰围、臀围、体重、BMI更大,差异有统计学意义(P<0.05)。膳食纤维联合运动干预后,试验组较对照组儿童的体重、BMI、腰围明显下降,空腹血糖、餐后2h血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、血压亦均明显下降(P<0.05);而两组低密度脂蛋白胆固醇差异无统计学意义(P>0.05)。结论肥胖儿童在临床上有显著糖脂代谢紊乱的特征。膳食纤维联合运动干预后患儿糖代谢、脂质代谢紊乱得到较好调节,血压变化较对照组明显降低。 Objective To analyze the clinical characteristics of obesity children with glycolipid metabolism and analyze the clinical effect of dietary fiber combined with exercise intervention in children. To understand the disorder of glucose and lipid metabolism in obese children and to reduce the risk of chronic diseases in adults and seniors . Methods A total of 110 children diagnosed as obese from Children’s Hospital of Qinghai Province from June 2013 to November 2014 were selected as obese group. Ninety children with normal physical examination were screened by the voluntary principle in the same period as the normal group. The height , Body weight, waist circumference, hip circumference, and body mass index (BMI) to compare the differences between these simple anthropometric data. At the same time, the obese children were randomly divided into two groups: the experimental group (55 cases) and the control group (55 cases). The experimental group adopted the dietary fiber diet combined with exercise intervention. The control group did not take special interventions. 5 weeks before and after the reflection of glucose metabolism, lipid metabolism of blood biochemical indicators, blood pressure changes. Results Compared with the normal group, the waist circumference, hip circumference, body weight and BMI in the obese group were significantly larger (P <0.05). After intervention with dietary fiber, the body weight, BMI and waist circumference of children in experimental group decreased significantly compared with those in control group. Fasting blood glucose, postprandial 2h blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol and blood pressure also decreased significantly (P <0.05). There was no significant difference between the two groups in LDL cholesterol (P> 0.05). Conclusion Obese children have clinically significant features of dyslipidemia. Dietary fiber combined with exercise intervention in children with glucose metabolism, lipid metabolism disorders are better adjusted, blood pressure changes were significantly lower than the control group.