本文证明安定0.05mmol/L能显著抑制由氯化钙诱发的大鼠离体子宫体肌收缩。安定0.07mmol/L及硝苯啶0.028及0.33μmol/L使氯化钙的剂量反应曲线非平行性右移并降低其最大收缩反应,其PD_2′值分别为4.241及7.55、6.91。表明安定的钙拮抗作用弱于硝苯啶,安定对由高钾去极化所引起的大鼠离体子宫体收缩和依赖细胞内钙的收缩均有抑制作用,安定对子宫的抑制作用可能是通过对钙的拮抗作用所致。 This article shows that the stability of 0.05mmol / L can significantly inhibit calcium chloride-induced rat uterine muscle contraction in vitro. The values ​​of PD 2 ’were 4.241 and 7.55, 6.91 for the stability of 0.07 mmol / L and nifedipine 0.028 and 0.33 μmol / L, respectively, by shifting the dose-response curve of calcium chloride to the right and decreasing the maximum contractile response. Indicating that stable calcium antagonism is weaker than nifedipine, diazepam induced by high potassium depolarization rat uterine contraction in vitro and dependent on intracellular calcium contraction are inhibited diazepam inhibition of the uterus may be Through the antagonism of calcium caused.