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目的:探讨大肠癌组织中基质金属蛋白酶-9(MM P-9)及其基质金属蛋白酶抑制剂-2(T IM P-2)的表达与临床病理指标之间的关系。方法:采用免疫组织化学S-P法检测108例大肠癌组织中MM P-9和T IM P-2蛋白的表达情况。结果:108例大肠癌组织中MM P-9和T IM P-2表达的阳性率分别为60.2%和25.0%;MM P-9的表达与肿瘤浸润深度、淋巴结转移、Dukes分期呈正相关,与生存期呈负相关,而T IM P-2的表达则相反;MM P-9和T IM P-2的表达与性别、年龄、肿瘤部位、病理类型和分化程度均无关。结论:MM P-9和T IM P-2可作为判断大肠癌恶性程度、转移及预后的重要参考指标。
Objective: To investigate the relationship between the expression of matrix metalloproteinase-9 (MMP-9) and matrix metalloproteinase inhibitor-2 (T IM P-2) and clinicopathological parameters in colorectal cancer. Methods: Immunohistochemical S-P method was used to detect the expression of MM P-9 and T IM P-2 protein in 108 cases of colorectal cancer. Results: The positive rates of MM P-9 and T IM P-2 expression in 108 cases of colorectal cancer were 60.2% and 25.0% respectively. The expression of MM P-9 was positively correlated with tumor invasion depth, lymph node metastasis and Dukes stage. There was a negative correlation between survival time and expression of T IM P-2. The expression of MM P-9 and T IM P-2 was not related to gender, age, tumor location, pathological type and differentiation. Conclusion: MM P-9 and T IM P-2 can be used as an important reference for judging the malignancy, metastasis and prognosis of colorectal cancer.