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对134例临床患者,胃镜直视下采粘膜标本做以下检测:1.应用CP试剂做尿素酶试验;2.按常规切片,HE染色,病理检查后再用1000倍油镜检菌。检测发现:1.消化道病CP阳性率为53.6％,显著高于正常粘膜11.11％(P<0.01);2.胃炎与溃疡急性活动期,CP阳性率69.44％,显著高于非活动期28.57(P<0.01);3.胃溃疡、十二指肠溃疡及复合性溃疡,CP阳性率分别为75.5％、54.0％、100％。其中2例多发性溃疡及3例复合性溃疡,CP阳性率为100％。4.对CP阳性的胃炎及溃疡患者,随机抽样25例,选用CP敏感庆大霉素治疗4周,其症状缓解率为84.0％,活动性炎症转为非活动性68.0％,CP转阴率88.0％,均显著高于对照组。结果提示:1.CP感染与上消化道慢性炎症及溃疡有相关性。2.加CP敏感的抗生素治疗有显著疗效。3.CP感染可能是上消化道慢性炎症与溃疡病的原因之一。
134 cases of clinical patients, gastroscopy mucosa under direct vision to do the following tests: 1. Use CP reagent urease test; 2. According to conventional sections, HE staining, pathology and then 1000 times oil microscopy. The results showed that: 1. The positive rate of CP in gastrointestinal disease was 53.6%, which was significantly higher than that in normal mucosa (11.11%) (P <0.01). 2. The positive rate of CP was 69.44% in the acute active stage of gastritis and ulcer, which was significantly higher than that of inactive stage 28.57 (P <0.01). 3. The positive rates of gastric ulcer, duodenal ulcer and composite ulcer were 75.5%, 54.0% and 100%, respectively. Two cases of multiple ulcer and three cases of complex ulcer, CP positive rate was 100%. CP-positive patients with gastritis and ulcer, a random sample of 25 cases, the selection of CP-sensitive gentamicin treatment for 4 weeks, the symptom relief rate was 84.0%, active inflammation was inactive 68.0%, CP negative rate 88.0%, were significantly higher than the control group. The results suggest: 1.CP infection and chronic upper gastrointestinal inflammation and ulcers are related. 2. Add CP-sensitive antibiotic treatment has a significant effect. 3.CP infection may be one of the causes of chronic inflammation and ulcer disease in the upper digestive tract.