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利用染煤石英混合粉尘大鼠作为实验模型，研究在实验性大鼠煤矽肺形成过程中肺泡巨噬细胞氧化和抗氧化系统的改变。结果表明在染煤石英粉尘７天，脂质过氧化产物有轻度升高，至３０天时己恢复正常，超氧化物歧化酶在染尘后７天降低，以后恢复至正常，而还原型谷胱甘肽和谷胱甘肽过氧化物酶升高明显，这与石英所致肺泡巨噬细胞的变化明显不同，说明脂质过氧化反应在煤矽肺形成过程中作用不明显。
In this study, we used the coal-dust mixture mixed with dust as experimental model to study the changes of the oxidation and anti-oxidation system of alveolar macrophages during the formation of coal silicosis in experimental rats. The results showed that during the 7 days of dying coal dust, the lipid peroxidation products increased slightly and returned to normal after 30 days. The superoxide dismutase decreased after 7 days of dying and then returned to normal, Glutathione and glutathione peroxidase increased significantly, which is significantly different from the changes of quartz alveolar macrophages, indicating lipid peroxidation in the process of coal silicosis is not obvious.