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以甲醇为溶剂,邻香草醛缩乙二胺席夫碱(H2vanen)与一水合醋酸铜[Cu(OAc)2·H2O]反应,合成了一种Valen席夫碱单核铜配合物[Cu(vanen)(H2O)].以盖斯定律为理论基础,设计了一个合理可行的热化学循环.根据该热化学循环,依次测定了各样品的标准摩尔溶解焓,进而求得配位反应的标准摩尔反应焓(θr m?H)为?(16.61±0.54)kJ/mol.再结合其他相关的文献值,求得配合物的标准摩尔生成焓(θf m?H)为?(756.5±2.4)kJ/mol.在32℃条件下,用热导式等温微量热仪测定了不同浓度配合物作用下粟酒裂殖酵母细胞的产热曲线,探讨了不同浓度的配合物对酵母菌生长的影响,分析了配合物的浓度与酵母菌代谢的生长速率常数k、抑制率I、最大发热功率Pmax、半抑制浓度IC50以及达到最大发热功率所需时间tmax等动力学参数之间的关系.分析结果表明,配合物对粟酒裂殖酵母细胞的生长具有低浓度促进、高浓度抑制的Hormesis效应.
In the presence of methanol, H2vanen was reacted with cupric acetate monohydrate [Cu (OAc) 2 · H2O] to synthesize a Cu-Cu complex [Cu vanen) (H2O)] .According to Gass’s theorem, a reasonable and feasible thermochemical cycle was designed.According to the thermochemical cycle, the standard molar enthalpy of solution for each sample was determined in turn, and then the standard of coordination reaction The molar enthalpy of formation (θr m -H) is (16.61 ± 0.54) kJ / mol. Combined with other relevant literature values, the standard molar enthalpy of formation (θf m- kJ / mol.The thermal curve of Schizosaccharomyces pombe under different concentrations of complex was determined by thermal conductivity isothermal microcalorimeter at 32 ℃, and the effect of different concentrations of complex on the growth of yeast was discussed , The relationship between the concentration of the complex and the kinetic parameters such as the growth rate constant k, the inhibition rate I, the maximum heating power Pmax, the half-inhibitory concentration IC50 and the time tmax to reach the maximum heating power was analyzed. It is indicated that the complex has a low concentration-promoting effect on the growth of Schizosaccharomyces pombe cells, the high concentration Hormesis effect.