基质金属蛋白酶9(MMP-9)是MMP家族的成员,在哮喘患者的气道、血清、痰和肺组织表达均升高,参与了哮喘中基质的重塑和炎性细胞的迁移。MMP-9还可能与重塑中气道平滑肌的增生、新血管的形成和杯状细胞的增生有关。引起哮喘气道重塑的因素常上调MMP-9的表达。多种药物可通过抑制MMP-9的表达或降低其活性以延缓或逆转气道重塑,这有望成为防治哮喘气道重塑的新方法。 Matrix metalloproteinase 9 (MMP-9), a member of the MMP family, is expressed in airway, serum, sputum and lung tissues in asthmatic patients and is involved in stromal remodeling and inflammatory cell migration in asthma. MMP-9 may also be involved in remodeling of airway smooth muscle hyperplasia, neovascularization and goblet cell hyperplasia. Factors that cause airway remodeling in asthma often up-regulate the expression of MMP-9. Various drugs can delay or reverse airway remodeling by inhibiting the expression of MMP-9 or decreasing its activity, which is expected to become a new method to prevent airway remodeling of asthma.