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目的研究RhoC与CD44v6在肝细胞癌(HCC)中的表达水平及临床意义。方法采用免疫组化SP法检测51例HCC中RhoC与CD44v6的表达。结果RhoC、CD44v6在HCC组织中的阳性表达均明显高于癌旁组织(P<0.01);RhoC和CD44v6在HCC中的表达与病理分级、肿瘤结节数、是否有淋巴转移、是否伴有门静脉侵犯有关(均P<0.05);而与性别、年龄、肿瘤直径、甲胎蛋白表达水平、有无乙肝病毒感染无关(均P>0.05)。RhoC和CD44v6阴性表达者无瘤生存时间均明显较RhoC和CD44v6阳性者长,RhoC与CD44v6在HCC组织中的表达呈正相关(P<0.01)。结论RhoC与CD44v6的表达可作为肝癌侵袭转移潜能及预后判断的指标。
Objective To study the expression of RhoC and CD44v6 in hepatocellular carcinoma (HCC) and its clinical significance. Methods Immunohistochemical SP method was used to detect the expression of RhoC and CD44v6 in 51 cases of HCC. Results The positive expression of RhoC and CD44v6 in HCC tissues was significantly higher than that in adjacent non-cancerous tissues (P <0.01). The expression of RhoC and CD44v6 in HCC was correlated with pathological grade, tumor nodules, lymphatic metastasis and portal vein (P <0.05). However, they were not related to gender, age, tumor diameter, alpha-fetoprotein expression and hepatitis B virus infection (all P> 0.05). The tumor-free survival time of RhoC and CD44v6-negative patients were significantly longer than that of RhoC and CD44v6-positive patients. The expression of RhoC and CD44v6 in HCC tissues was positively correlated (P <0.01). Conclusions The expression of RhoC and CD44v6 can be used as indicators of invasion and metastasis and prognosis of liver cancer.