胃泌素既是一种胃肠激素,又是一种脑-肠肽,它广泛分布于中枢神经系统,脑脊液和迷走种经。然而胃泌素在脑内存在的生理意义,迄今了解甚少,它对胃肠运动有何作用亦未见报道。本文观察了侧脑室注射微量五肽胃泌素(G_5)对胃肠推进运动的影响,并对其作用机理进行了初步的探讨。 Gastrin is a gastrointestinal hormone, but also a brain-gut peptide, which is widely distributed in the central nervous system, cerebrospinal fluid and vagus nerve. However, the physiological significance of gastrin present in the brain, so far little understood, and its role in gastrointestinal motility has not been reported. In this paper, the effects of intracerebroventricular injection of a small amount of pentagastrin (G_5) on gastrointestinal motility were observed and the mechanism of action was also discussed.