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环孢素(Cyclosporine A,CsA)是一种从真菌中得到的大环内酯类物质,为选择性的T淋巴细胞钙调神经磷酸酶抑制剂,主要用于器官移植术后的抗排斥反应和某些自身免疫性疾病的治疗。据文献报道CsA治疗窗浓度的高低与疗效及毒性密切相关。采用适宜的治疗窗浓度是保证疗效、减少
Cyclosporine A (CsA), a macrolide derived from fungi, is a selective T-lymphocyte calcineurin inhibitor that is mainly used in anti-rejection after organ transplantation And some autoimmune diseases. It is reported in the literature that the level of CsA therapeutic window is closely related to efficacy and toxicity. The use of appropriate therapeutic window concentration is to ensure efficacy and reduce