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[目的]探讨精吡氟禾草灵(Fluazifop-p-butyl)对大鼠的亚慢性毒性,求出最大无作用剂量。[方法]按照GB15670-1995《农药登记毒理学试验方法》中亚慢性90d毒性方法,雌雄性大鼠设低(163、290 mg/kg饲料)、中(653、1160 mg/kg饲料)、高(2610、4640 mg/kg饲料)3个剂量组和1个对照组,测试指标包括血液学、尿液、血液生化检查,病理学检查,每周一次测定体重、进食量,到期解剖测定脏器重量,对结果进行统计学处理。[结果]精吡氟禾草灵高剂量组雌雄性大鼠总摄食量低干对照组,肝/体值、肾/体值高于对照组,雄性大鼠脑/体值高于对照组,脾/体值、睾丸/体值低于对照组;中剂量组雄性大鼠脑/体值、肝/体值、肾/体值高于对照组,脾/体值低于对照组。高剂量组睾丸组织病理学检查可见组织形态学改变。[结论]精吡氟禾草灵可引起SD大鼠睾丸生殖细胞病变;最大无作用剂量雌性为(55.72±4.13)mg/(kg·d),雄性为(22.05±1.56)mg/(kg·d)。
[Objective] To investigate the sub-chronic toxicity of Fluazifop-p-butyl to rats and find the maximum no-effect dose. [Method] According to the chronic toxicity test of 90 days in Central Asia, GB15670-1995 “Toxicological Test of Pesticide Registration”, the male and female rats were set low (163,290 mg / kg feed), middle (653,1160 mg / (2610,4640 mg / kg feed), and one control group. The test indexes included hematology, urine, blood biochemical examination, pathological examination, body weight and food intake once a week, Weight, the results of the statistical treatment. [Result] The total intake of male and female rats in the high-dose fluazifosulfuron high dose group was lower than that in the control group, liver / body weight, kidney / body value was higher than that in the control group, Spleen / body weight and testis / body weight were lower than those of the control group. The brain / body weight, liver / body weight and kidney / body weight of the middle-dose group were higher than those of the control group. High-dose testicular histopathological examination revealed histological changes. [Conclusion] Fluazifop + can induce the testicular germ cell lesions in SD rats. The maximum effective dose was (55.72 ± 4.13) mg / (kg · d) and the male was (22.05 ± 1.56) mg / (kg · d).