Objective:To observe the effects of acupuncture at different times on plasma thromboxane (TXB2) and prostaglandin 6-Keto-PGF1a (6-K-P) in patients with ischemic cerebrovascular disease. Methods: Totally 90 patients were randomly divided into a group acupunctured at 7-9 am, a group acupunctured at 3-5 pm and a drug control group, with 30 cases in each group. The contents of plasma TXB2 and 6-K-P from venous blood before treatment were compared with those 15 days after treatment. Results: The plasma TXB2 levels of the two acupuncture groups were obviously lower than those before treatment (P<0.05, P<0.01), but the 6-K-P levels of both the acupuncture groups were remarkably higher than those before treatment (P<0.05, P<0.01). And the TXB2 level in the 3-5 pm acupuncture group was obviously lower than that in the 7-9 am acupuncture group (P<0.05), and the 6-K-P level of the former was obviously higher than that of the latter (P<0.05). Conclusion: Acupuncture can promote functional recovery in patients with ischemic cerebrovascular disease and enhance their survival quality.