Ehrlich,P.首先发现了人体能鉴别自己和非己。后来Burnet,F.M.提出了克隆选择学说,即人体内存在着不同的淋巴细胞克隆,分别对不同的特异性抗原发生反应。能对自身抗原发生反应的淋巴细胞克隆因在生命的早期与自身抗原相接触而被清除或者是被灭活了,所以在正常情况下,不发生严重的自身免疫反 Ehrlich, P. first discovered that the human body can identify itself and others. Later Burnet, F.M. put forward the theory of clonal selection, that is, there are different lymphocyte clones in human body, which react to different specific antigens. Lymphoid clones that react to their own antigens are either erased or inactivated by their contact with autoantigens in the early stages of their lives, so that under normal circumstances, no serious autoimmune reaction occurs