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目的:研究柴胡疏肝散不同配伍对柴胡皂苷a溶出量的影响。方法:采用L8(27)正交设计法,以HPLC-DAD测定各配伍样品中柴胡皂苷a的含量,并对数据进行单因素方差分析。结果:正交设计各因素对柴胡皂苷a溶出率的影响大小为使药>佐药>臣药。单因素对其影响均有显著性差异,交互作用无显著性差异。4组分法中,各组间均有显著性差异。不同药味数分组中,各大组之内不同配伍柴胡皂苷a溶出率不同,各组间溶出率:复方>五五配伍>单煎液>六六配伍、两两配伍>四四配伍>三三配伍。结论:含有白芍、香附、川芎的配伍组中柴胡皂苷a的溶出率较低,含有枳壳和甘草配伍组中柴胡皂苷a的溶出率较高,全方组中柴胡皂苷a的溶出率最高。
Objective: To study the effect of different compatibility of Chaihu Shugan Powder on dissolution of saikosaponin a. Methods: The orthogonal design of L8 (27) was used to determine the content of saikosaponin a in each compatibility sample by HPLC-DAD. The data were analyzed by one-way ANOVA. Results: The orthogonal design factors of saikosaponin a dissolution rate of the size of the drug> adjuvant> Chen medicine. The influence of single factor has significant difference, the interaction has no significant difference. 4 component method, the groups were significantly different. Difference in the number of drugstuffs within the group within the different compatibility saikosaponin a dissolution rate, the dissolution rate among the groups: compound> five or five compatibility> single decoction> sixty-six compatibility, two hundred and twenty-two compatibility> forty-four compatibility> three Three compatibility. CONCLUSION: The dissolution rate of saikosaponin a in compatibility group containing Radix Paeoniae Alba, Radix Angelicae Sinensis and Chuanxiong is lower, the dissolution rate of saikosaponin a in compatibility group containing Fructus Aurantii and licorice is higher, and the dissolution rate of saikosaponin a The highest dissolution rate.