青霉素G从四十年代初应用于临床至今已40多年了,由于它毒性低,疗效高,所以在临床上得到了长期广泛的应用。但是,随之而来的是在五十年代末就发现有对它耐药的细菌,尽管在六十年代开始出现的半合成青霉素和半合成头孢菌素在治疗耐青霉素G的细菌感染疾患方面取得了很大效果,但是还有一些细菌特别是肠杆菌、肠球菌类致病菌对青霉素类及头孢菌素类抗生素耐药。 Penicillin G has been used clinically for more than 40 years since its early forties. Due to its low toxicity and high therapeutic effect, penicillin G has been widely used clinically for a long time. However, what followed was the discovery of bacteria resistant to it in the late 1950s, although the semisynthetic penicillins and semisynthetic cephalosporins that began to appear in the 1960s have been used to treat bacterial infections that are resistant to penicillin G Great results have been achieved, but there are some bacteria, especially Enterobacteriaceae, enterococci pathogens resistant to penicillins and cephalosporins.