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目前,采用单克隆抗体研究癌抗原的工作进展很快,多种肿瘤标记物相继问世。随着一级结构的阐明,现已获知,多数胰腺癌标记物决定癌抗原的部分位于糖链。糖类抗原50(CA 50)是Lindholm在1982年发现的一种糖脂,用大肠癌Colo-205的培养细胞免疫小鼠而获得的单克隆抗体C-50可以识别这种糖脂。此物质存在于正常的消化道、肝脏、胰腺、及腮腺等组织中,如果上述脏器出现癌变,则血中浓度就增高。关于其阳性率,据报告胰腺癌约为85%;胆道系统的癌
At present, the use of monoclonal antibodies to study cancer antigens is progressing rapidly, and a variety of tumor markers have emerged one after another. With the elucidation of the primary structure, it has now been learned that most pancreatic cancer markers determine that part of the cancer antigen is located in the sugar chain. Carbohydrate Antigen 50 (CA 50) is a glycolipid discovered by Lindholm in 1982. The monoclonal antibody C-50 obtained by immunizing mice with cultured cells of colon cancer Colo-205 recognizes this glycolipid. This substance is present in the normal digestive tract, liver, pancreas, and parotid glands. If the above organs become cancerous, the blood concentration increases. About its positive rate, pancreatic cancer is reported to be about 85%; cancer of the biliary system