目的探讨放疗结合化疗对晚期乳腺癌的疗效。方法将88例晚期(Ⅲ或Ⅳ期)乳腺癌患者分为两组:放疗结合化疗组(A组)45例;单纯放疗组(B组)43例。A组放疗前接受CMF或FAC方案化疗3个疗程,每周1次,化疗结束后休息1周开始放疗。B组行单纯性放疗。两组放疗剂量6400-7800cGy,两组放疗方法、时间、剂量分割均相同。结果(1)A组的近期疗效(CR+PR)为91%,高于B组的67.4%(P<0.05);(2)A组的骨髓抑制及胃肠反应发生率高于B组(P<0.05);(3)A组、B组的1年生存率分别为97.8%和93%,差异无显著性,A组2、3、5年生存率分别为86.7%、66.7%和48.8%,高于B组的67.4%、39.5%和23.8%(P<0.05)。结论放疗结合化疗可提高晚期乳腺癌患者的近期疗效及2、3、5年生存率,但骨髓抑制及胃肠反应增加。 Objective To investigate the effect of radiotherapy combined with chemotherapy on advanced breast cancer. Methods Eighty-eight patients with advanced stage (stage III or IV) breast cancer were divided into two groups: 45 cases treated with radiotherapy combined with chemotherapy (group A) and 43 cases treated with radiotherapy alone (group B). In group A, 3 cycles of CMF or FAC regimen chemotherapy were administered before radiotherapy, once a week, and radiotherapy was started one week after the end of chemotherapy. Group B was treated with simple radiotherapy. The two groups of radiation dose 6400-7800cGy, the two groups of radiotherapy methods, time, dose division are the same. Results (1) The short-term efficacy (CR+PR) in group A was 91%, which was higher than that in group B (67.4%) (P<0.05). (2) The incidence of myelosuppression and gastrointestinal reactions in group A was higher than that in group B ( P<0.05); (3) The one-year survival rates of group A and group B were 97.8% and 93%, respectively, with no significant difference. The survival rates of group A, 3, and 5 years were 86.7%, 66.7%, and 48.8 respectively. %, higher than 67.4%, 39.5% and 23.8% of group B (P<0.05). Conclusion Radiotherapy combined with chemotherapy can improve the short-term efficacy and survival rate at 2, 3, and 5 years in patients with advanced breast cancer, but the bone marrow suppression and gastrointestinal reactions increase.