Echinodol(l)是1993年由Hartmann等从生长于巴西的一种药用植物(Echinodorusgrandiflorus)的叶子中分离鉴定出的含羟基的西松烷(Cembrane)型大环二萜天然产物.它是具有显著抗肿瘤活性的大环二萜天然产物Sarcophytol-A(2)的异构体.有关1的生物活性试验及其全合成尚未见文献报道.文献[3]中我们曾报道了1的前体化合物的合成,本文报道其全合成.我们以全反式 Echinodol (l) was isolated from the leaves of a medicinal plant Echinodorus grandiflorus grown in Brazil by Hartmann et al. In 1993. It is a natural product of the macrocyclic diterpene containing hydroxyl group, Cembrane, The antitumor activity of the large ring diterpene natural product Sarcophytol-A (2) isomers .About 1 biological activity of the test and its total synthesis has not been reported in the literature [3] we have reported a precursor compound The synthesis reported here is fully synthetic. We are all trans