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大量流行病学研究表明，高脂血症是动脉粥样硬化等心血管疾病的重要物质基础。构建高脂血症动物模型时，选用合理的高脂配方和合适的动物尤为关键。由胆固醇、胆盐、蛋黄粉、猪油或花生油、丙基硫氧嘧啶等成分构成的高脂饲料配方，在不同实验中可能各成分所占整个饲料的比重有所不同，高脂饲料各成分之间的差异可能适合不同实验目的的需要；高脂模型的动物选择，主要基于各种动物自身生理解剖学特点，这将有助于研究者选择合适的动物。因此基于高脂配方和动物特点的分析，为高脂血症的动物模型选择提供了依据。“,”A large number of epidemiological studies have shown that hyperlipidemia is a key risk factor of atherosclerosis.It is particularly important to choose a reasonable high-fat formula and suitable animal when building hyperlipidemia models.The high-fat diet is made up of cholesterol, bile salts, egg yolk pow-der,propylthiouracil,lard or peanut oil.Different proportions of the components in high-fat diet will help researchers to choose appropriate high-fat formula based on its role in the formula.As for the hyperlipidemia animal models,it′s mainly based on the physiological anatomy characteristics of different animals, which could help the researchers to choose an appropriate animal.Here provides a reference to choose appropriate diet and suitable animal to build hyperlipidemia models, based on the analysis of high-fat formula and fea-tures of different animals.