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目的 :研究p2 7、ki 6 7在喉鳞癌中的蛋白表达水平及其临床意义。方法 :应用免疫组织化学S P法检测p2 7蛋白、ki 6 7抗原在 5 2例喉鳞癌以及 18例癌旁组织中的表达状况。结果 :p2 7蛋白在喉鳞癌中表达阳性率 (5 7.7% )低于癌旁组织 (88.9% ) ,P <0 .0 5 ;p2 7的表达与喉鳞癌患者肿瘤T分级和临床分期呈显著负相关 ,与肿瘤部位、肿瘤分化程度、颈淋巴结转移无关。ki 6 7抗原在喉鳞癌中表达阳性率 (5 5 .8% )高于癌旁组织 (0 % ) ,P <0 .0 1;ki 6 7的表达与喉鳞癌患者肿瘤分化程度呈显著正相关 ,与肿瘤部位、T分级、临床分期、颈淋巴结转移无关。p2 7与ki 6 7的表达在喉鳞癌中无负相关关系。结论 :p2 7蛋白表达可为正确判断肿瘤T分级、临床分期提供新的依据 ;而ki 6 7抗原表达则可为正确判断肿瘤分化程度提供新的依据 ,具有一定的临床意义
Objective: To study the expression of p27 and ki67 in laryngeal squamous cell carcinoma and its clinical significance. Methods: The expression of p27 protein and ki67 antigen in 52 cases of laryngeal squamous cell carcinoma and 18 cases of paracancerous tissues was detected by immunohistochemical SP method. Results: The positive rate of p27 protein expression in laryngeal squamous cell carcinoma (5 7.7%) was lower than that in paracancerous tissues (88.9%), P <0.05; p27 expression was significantly correlated with T stage and clinical stage Was significantly negative correlation with the tumor site, tumor differentiation, cervical lymph node metastasis. The positive rate of ki 6 7 antigen in laryngeal squamous cell carcinoma (55.8%) was higher than that in paracancerous tissues (0%), P <0.01; the expression of ki 6 7 was correlated with the degree of tumor differentiation in laryngeal squamous cell carcinoma Significantly positive correlation with tumor location, T grade, clinical stage, cervical lymph node metastasis. There was no negative correlation between the expression of p27 and ki 6 7 in LSCC. CONCLUSION: The expression of p27 protein provides a new basis for correctly judging the T grade and clinical stage of tumor, while the expression of ki 6 7 antigen can provide a new basis for judging the differentiation degree of tumor, and has certain clinical significance