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[目的]探讨脂联素基因I164T变异与2型糖尿病的关系.[方法]选择312例无亲缘关系的延边地区朝鲜族和汉族人群,其中糖耐量正常组为155名,2型糖尿病组为157名.采用PCR-SSCP方法对脂联素基因I164T突变进行初筛分析,并对不同带型的标本进行DNA直接序列测定.[结果]两组中均未发现I164T变异.[结论]脂联素基因I164T变异可能不是延边地区朝鲜族和汉族人群2型糖尿病的易感基因.
[Objective] To explore the relationship between the I164T mutation of adiponectin gene and type 2 diabetes. [Methods] A total of 312 unrelated Korean and Han nationality in Yanbian area were selected, including 155 with normal glucose tolerance group and 157 with type 2 diabetes mellitus group Were used to detect the I164T mutation of adiponectin gene by PCR-SSCP method, and DNA sequence analysis was performed on different band samples. [Results] No mutation of I164T was found in both groups. [Conclusion] Adiponectin The gene I164T mutation may not be a susceptible gene for type 2 diabetes in Korean and Han populations in Yanbian.