基因表达系列分析技术(SAGE)是基因表达定性和定量研究的一种新的有效手段。它不需要事先知道其基因序列,能同时对数千个转录体的丰度进行定量研究。近年来人们利用此技术对正常和疾病组织细胞的基因表达信息进行了广泛的研究,作者就SAGE在消化道肿瘤研究中的应用进展作一综述。 Serial analysis of gene expression (SAGE) is a new and effective means of qualitative and quantitative study of gene expression. It does not require prior knowledge of its gene sequence and can simultaneously quantify the abundance of thousands of transcripts. In recent years, people have used this technique to extensively study the gene expression information of normal and diseased tissue cells. The authors reviewed the progress of SAGE in the research of gastrointestinal tumors.