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低酚棉籽仁（GCK）的毒理学研究表明，在100％纯GCK饲喂大鼠1周的急性毒性试验中，无一死亡和异常反应。饲料中含40％和20％GCK的长期毒性（6个月）试验中，与对照组比，受试大鼠进食量正常，体重增长一致，无中毒反应。血液学和血清生化的测定指标均在正常范围，脏器系数和病理学检查无异常，试验与对照间的统计分析无显著差异。提示GCK对受试大鼠无急性和长期毒性影响。
Toxicology studies of low phenolic cottonseed kernels (GCK) showed no death and abnormal reactions in a one-week acute toxicity test in rats fed 100% pure GCK. In the long-term toxicity (6 months) test of feed containing 40% and 20% GCK, compared with the control group, the rats in the test had normal food intake, consistent weight gain, and no toxic reactions. The indices for hematology and serum biochemistry were within the normal range, and there was no abnormality in organ coefficient and pathological examination. There was no significant difference between the statistical analysis of the test and the control. It is suggested that GCK has no acute and long-term toxic effects on the rats.