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目的探讨体外反搏术治疗小儿难治性癫痫的远期疗效。方法对9例难治性癫痫患儿在原用抗癫痫药物(AEDs)不变的基础上,辅佐体外反搏治疗,每次持续60 min,每10天为1个疗程,共6个疗程。观察体外反搏治疗前后发作频率的改变及远期随访疗效、不良反应,以及对脑电生理及癫痫灶局部脑血流的影响。结果体外反搏治疗组治疗后癫痫发作明显减少,治疗组9例患儿跟踪随访2年,其中5例未见癫痫发作,2例癫痫发作明显减少,1例无效;对照组1例未见癫痫发作,2例癫痫发作次数减少,5例无效。体外反搏治疗后脑血流灌注好转率达77.8%,痫性放电现象明显减少,转阴率55.6%。两组疗效比较,差异具有统计学意义(P<0.01)。结论体外反搏治疗小儿难治性癫痫疗效肯定,远期疗效显著。
Objective To investigate the long-term efficacy of EECP in the treatment of refractory epilepsy in children. Methods Nine children with refractory epilepsy were supplemented with EECP on the basis of the same antiepileptic drugs (AEDs). Each treatment lasts 60 min every 10 days for a course of 6 courses. To observe the change of seizure frequency and long-term follow-up curative effect and adverse reaction before and after EECP treatment, as well as the influence on cerebral electrophysiology and local cerebral blood flow of epileptic foci. Results EECP treatment group decreased significantly after treatment of seizures, the treatment group of 9 patients were followed up for 2 years, 5 cases did not have seizures, 2 cases of seizures decreased significantly, 1 case of ineffective; 1 case of control group without epilepsy Attack, 2 cases of seizures decreased, 5 cases of invalid. Embolism after treatment of cerebral perfusion improved rate of 77.8%, epileptiform discharge significantly reduced the phenomenon, the negative rate of 55.6%. The efficacy of the two groups, the difference was statistically significant (P <0.01). Conclusion Extracorporeal counterpulsation is effective in the treatment of refractory epilepsy in children, and the long-term curative effect is obvious.