Setleis综合征为一种少见的常染色体隐性遗传病。于1963年由Setleis等首次报告。本文作者报告2例,迄今共有8例报告。作者综合本病的临床表现具有以下特征:(1)双颞凹陷,并有皮肤先天发育不全;(2)眼眶周围浮肿,似老人貌;(3)两眉向外上,且远端缺如;(4)睫毛畸形,如上睑倒睫,下睑无睫毛,部分病人有慢性睑缘炎;(5)鼻畸形,鼻梁扁平,球形鼻尖,鼻隔延伸于鼻翼以下;(6)皮肤的移动性增加,上唇内结缔组织增多,面部软组织明显丰满。个别病人尚有 Setleis syndrome is a rare autosomal recessive disease. First reported by Setleis et al. In 1963. The authors report 2 cases, so far a total of 8 cases reported. The author combines the clinical manifestations of this disease has the following characteristics: (1) double temporal recess and skin congenital hypoplasia; (2) orbital edema, like the elderly appearance; (3) two brows outward, and the distal lack ; (4) eyelashes deformities, such as the upper eyelid trichiasis, lower eyelid no eyelashes, some patients have chronic blepharitis; (5) nasal deformity, flat nose, nasal tip, nasal septum extends below the nose; Increased sexual, upper connective tissue increased, facial soft tissue significantly plump. Individual patients still have