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[目的]探讨全颈同步加量容积调强放疗(WF-SIB VMAT)在鼻咽癌治疗中的可行性。[方法]对于8例入组的鼻咽癌患者,根据相同的优化目标,分别设计了7野WF-SIB IMRT、单弧WF-SIB VMAT和双弧WF-SIB VMAT计划。对三种治疗方式的靶区覆盖率与正常组织的保护情况进行比较分析,并分析比较优化时间、传输时间及剂量验证通过率等指标。[结果]IMRT的靶区覆盖率比单弧和双弧VMAT计划高,双弧VMAT的脊髓最大剂量点最低,其他参数比较没有统计学差异。单弧与双弧VMAT计划优化时间分别是IM-RT的5倍与10倍,MU只有IMRT的42%与55%左右,出束时间分别比IMRT快6倍和3倍。[结论]双弧VMAT可行,WF-SIB VMAT与IMRT可同作为鼻咽癌的治疗选择。
[Objective] To investigate the feasibility of total neck synchronized volume-modulated radiation therapy (WF-SIB VMAT) in the treatment of nasopharyngeal carcinoma. [Methods] For the 8 patients with nasopharyngeal carcinoma, the 7-field WF-SIB IMRT, the single-arc WF-SIB VMAT and the double-arc WF-SIB VMAT were designed according to the same optimization goals. The target area coverage and the protection of normal tissue of three treatment methods were compared and analyzed, and the indexes such as comparison and optimization time, transmission time and dose verification pass rate were analyzed. [Results] The target area coverage of IMRT was higher than that of single-arc and double-arc VMAT. The maximum dose of spinal cord of dual-arc VMAT was the lowest, and the other parameters were not statistically different. The single-arc and double-arc VMAT program optimization time is 5 times and 10 times that of IM-RT respectively, MU is only 42% and 55% of IMRT, and the beam-out time is 6 and 3 times faster than IMRT respectively. [Conclusion] The double-arc VMAT is feasible and WF-SIB VMAT and IMRT can be used as the treatment options for nasopharyngeal carcinoma.