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为观察补充锌、铜对染砷小鼠的肝、肾脏组织超氧化物歧化酶 (SOD)水平、丙二醛 (MDA)含量并初步探讨其作用机制 ,对染砷小鼠同步进行锌、铜干预试验 ,同时作肝脏、肾脏组织SOD活性及MDA含量测定和病理学观察。干预后 ,与阳性对照组相比 ,锌干预组肝脏、肾脏SOD活性升高 ,MDA含量下降 (P <0 .0 1) ,锌加铜组仅肾脏SOD活性升高 (P <0 .0 1) ,铜组肝、肾脏SOD活性及MDA含量均无显著性差异 (P >0 .0 5 )。病理学观察可见 ,锌干预组效果最好 ,其次为锌加铜组 ,而铜组无干预效果。提示补充一定剂量锌对染砷小鼠的脂质过氧化程度、抗氧化能力以及组织病理改变均有一定的干预效应。铜在该剂量下与锌起拮抗作用。
In order to observe the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in the liver and kidney of arsenic-exposed mice with zinc and copper supplementation and to explore its mechanism, Intervention experiments, at the same time as the liver, kidney SOD activity and MDA content and pathological observation. Compared with the positive control group, the activity of SOD in the liver and kidney increased and the content of MDA decreased (P <0.01) in the zinc intervention group, but increased in the kidney of the zinc plus copper group (P <0.01) ), There was no significant difference in SOD activity and MDA content in liver and kidney of copper group (P> 0.05). Pathological observation shows that zinc intervention group was the best, followed by zinc plus copper group, while the copper group without intervention. It is suggested that supplementation of a certain dose of zinc has a certain intervening effect on lipid peroxidation, antioxidative ability and histopathological changes in arsenic-exposed mice. Copper antagonized zinc at this dose.