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目的 了解珠蛋白生成障碍性贫血（简称地贫）患儿伴缺铁的发生率，探讨其临床意义。方法 对127例确诊地贫儿进行铁指标（SF、SI、TIBC、FEP）的检测。结果 127例中缺铁者28例(22 %)，其中α型占19 %(4/21)，β型占22.6 %(24/106)，两者无显著差异 (P＞0.5)。β型地贫并缺铁者HbF＜30 %组占38.8 %(19/49)， HbF≥30 %组占8.8 %(5/57)，差异显著 (P＜0.005)。HbF＜30 %组＜3 a者的缺铁率明显高于＞3 a者(53.3 %vs 15.8 %, P＜0.01)。结论 地贫儿可能伴发铁缺乏，尤其是低HbF的婴幼儿缺铁率更高，有必要对其进行适当补铁治疗。
Objective To understand the incidence of iron deficiency in children with globin genesis-related anemia (ALT) and to explore its clinical significance. Methods 127 iron deficiency patients (SF, SI, TIBC, FEP) were detected. Results Of the 127 cases, 28 cases (22%) had iron deficiency. Among them, α type accounted for 19% (4/21) and β type accounted for 22.6% (24/106). There was no significant difference between the two groups (P> 0.5). β-thalassemia and iron deficiency were 38.8% (19/49) in HbF <30% group and 8.8% (5/57) in HbF≥30% group (P <0.005). The iron deficiency rate in HbF <30% and <3 a groups was significantly higher than that of> 3 a (53.3% vs 15.8%, P <0.01). Conclusion Thalassemia may be associated with iron deficiency, especially in infants with low HbF iron deficiency rate is higher, it is necessary to appropriate iron treatment.