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设计口服结肠靶向的递送系统对于治疗结肠有关的疾病非常重要,因为这种方式能够使药物精确施用到病变部位,提高药物生物利用度和患者的顺应性.尤其,以纳米粒子为基础的口服制剂可以保护药物在恶劣的胃肠道环境中不被破坏,并选择性地增加病变结肠部位的药物浓度,从而提高治疗功效、降低全身毒性.本文阐述了这方面的最新进展,重点总结了结肠部位的病生理特征和以此为依据的靶向设计策略.
Designing an oral colon-targeted delivery system is important for the treatment of colon-related diseases as this approach enables the precise application of the drug to the site of the lesion, improving drug bioavailability and patient compliance, and in particular, nanoparticle-based oral Preparation can protect the drug in the harsh gastrointestinal environment is not destroyed, and selectively increase the concentration of drug concentration in the lesion of the colon, thereby enhancing the efficacy of treatment and reduce systemic toxicity.This article describes the latest developments in this area, focusing on the colon Site of the disease physiology characteristics and based on the targeted design strategy.