有人报告,带氟的类固醇激素制剂引起的局部不利反应有所增加,如皮肤萎缩和显著的易脆性、酒渣鼻的加重、真菌感染症状的抑制,以及引起口周皮炎等。这就提出了寻求一种具有治疗效用且副作用较小的类固醇制剂的需要。在很多病例中,天然的氢化可的松和上述的不利反应是无关的。如能加入于一种可以提高其吸收作用的基质内,则将更为有利。为了使局部应用氢化可的松获得满意的效果,减小其微粒的体积是必要的。这在软膏制剂和霜剂中已经证实。如能在一适当的溶剂中使氢化可的松溶解,使其微粒减小至 It has been reported that unfavorable local adverse reactions such as skin atrophy and significant brittleness, aggravation of rosacea, inhibition of fungal infection, and perioral dermatitis have been reported with steroid hormone preparations containing fluorine. This raises the need to find a steroid formulation that has therapeutic utility with less side effects. In many cases, native hydrocortisone is unrelated to the adverse reactions described above. It would be more advantageous to incorporate it into a matrix that enhances its absorption. In order to obtain satisfactory results for topical application of hydrocortisone, it is necessary to reduce the volume of its microparticles. This has been demonstrated in ointment preparations and creams. Hydrocortisone can be dissolved in a suitable solvent to reduce its particle size to