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环境介质中以低剂量存在的内分泌干扰物(EDCs)具有相似的作用终点,可能通过多种机制表现出联合作用。目前EDCs的毒性研究多针对单个化合物进行,各EDCs之间,尤其不同作用类型EDCs之间的联合作用模式尚不明确,无法为这一类物质的健康风险评估提供科学依据。近年来,化合物累积暴露风险评估方法逐渐建立起来,这些方法将在评估EDCs联合暴露风险中具有很好的应用前景。本文将对EDCs联合作用的研究和累积风险评估方法进行综述,以期为EDCs联合暴露评估提供参考。
Endocrine disruptors (EDCs), present at low doses in environmental media, have similar endpoints of action and may show a synergistic effect through multiple mechanisms. At present, the studies on the toxicity of EDCs are mostly performed on a single compound. The mode of combined action among EDCs, especially among EDCs with different types of action is not yet clear and can not provide a scientific basis for the assessment of health risks of these substances. In recent years, cumulative exposure risk assessment methods of compounds gradually established, these methods will have a good application prospect in assessing the combined exposure risk of EDCs. This article reviews the combined effects of EDCs and the cumulative risk assessment methods to provide a reference for the assessment of EDCs combined exposure.