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目的 研究脑胶质瘤细胞中AgNOR染色与Ki 67阳性表达间的关系以及与病人预后的关系。方法 45例脑胶质瘤标本行AgNOR染色。 13例新鲜脑胶质瘤标本同时行Ki 67免疫组化染色。 3 0例获随访病例作AgNOR计数的生存统计。 结果 AgNOR计数与组织病理分级正相关并与Ki 67呈线性正相关。AgNOR计数 <1 80病例组预后明显好于AgNOR计数≥ 1 80病例组。 结论 AgNOR计数是一项反映了脑胶质瘤良恶性程度的定量指标 ,可作为肿瘤细胞动力学参数的间接指标 ,并与病人预后相关
Objective To study the relationship between the expression of AgNOR and the positive expression of Ki 67 in glioma cells and the prognosis of patients. Methods 45 glioma specimens were stained with AgNOR. 13 cases of fresh glioma specimens simultaneously Ki 67 immunohistochemical staining. 30 cases were followed up for AgNOR count survival statistics. Results AgNOR count was positively correlated with histopathological grade and positively correlated with Ki 67. AgNOR count <180 cases of the prognosis was significantly better than the AgNOR count ≥ 180 cases. Conclusion The AgNOR count is a quantitative indicator reflecting the gliomas’ benign and malignant degree, which can be used as an indirect indicator of tumor cell kinetic parameters and is related to the prognosis