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舒血管肠肽(VIP) 是一种胃肠激素,在许多方面符合神经递质的特点。VIP在体内分布甚少;但有广泛的生物学作用。有迹象提示;VIP可能参与调节垂体前叶激素(如催乳素)的分泌并可能影响生殖系统的功能。作者使用成年雌兔,观察到以下结果:(1)给动情期雌兔静脉点滴60min VIP(37.5、76和150pmol/kg/min),可明显提高血浆孕酮水平,剂量与反应相关;VIP也能明显提高给予排卵刺激物以后的血浆孕酮峰值,但在两种情况下,VIP对血浆雌二醇及睾酮水平皆无明显影响。(2)VIP不改变血浆催乳素水平,预先用使催乳素水平降低的药物(溴隐亭)也不影响VIP提高血浆孕酮水平的作用。(3)点滴VIP,对雌兔的卵子检拾率、卵运输距离以及生育力(黄体数,着床点及存活孕体数)皆无明显影响。以上结果表明,
Vasoactive intestinal peptide (VIP) is a gastrointestinal hormone that is characteristic of neurotransmitters in many ways. VIP is rarely distributed in the body; however, it has a wide range of biological effects. There are indications that VIP may be involved in regulating the secretion of anterior pituitary hormones (such as prolactin) and may affect the reproductive system function. The authors observed the following results using adult female rabbits: (1) VIP (37.5,76 and 150pmol / kg / min) intravenous drip for estrous females for 60min significantly increased the plasma progesterone level, and the dose was related to the response; VIP Can significantly increase the plasma progesterone peak after administration of ovulation stimuli, but in both cases, VIP had no significant effect on plasma estradiol and testosterone levels. (2) VIP does not change the level of plasma prolactin, pre-use of drugs that reduce the level of prolactin (bromocriptine) does not affect the role of VIP to increase plasma progesterone levels. (3) Dripping VIP, no significant effect was found on the egg picking rate, egg transport distance, fertility (luteal number, implantation site and number of surviving ones). The above results show that,