Knorr-Paal缩合曾被片面地把它与呋喃、噻吩等概列为通过烯醇化缩合的反应,这就掩盖了它的反应原理在合成化学上的通用性并阻碍了它的推广前途。现在它的反应机理已初步揭示,发现这个机理不单在杂环合成上有用,在生源式合成和生物合成的研究上也有广泛用途。大家知道鉴定羰基化合物有一些简单的试剂反应,在机理上这些反应与Knorr-Paal反 Knorr-Paal condensation was one-sidedly classified as furan, thiophene and the like by condensation reaction of enolase, which obscured the generalization of its reaction principle in synthetic chemistry and hindered its promotion. Now its reaction mechanism has been tentatively revealed and found that this mechanism is not only useful in heterocyclic synthesis, but also widely used in the study of biosynthesis and biosynthesis. We all know that the identification of carbonyl compounds have some simple reagent reactions, in the mechanism of these reactions and Knorr-Paal anti