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本文对拟诊急性心肌梗塞(AMI)患者于发病后5小时内静脉给予β阻滞剂噻吗心安或安慰剂的一项随机双盲多中心研究结果。文中用累积肌酸磷酸激酶释放指数和连续心向量图记录分析的方法来衡量心肌损伤范围,以克服既往一些报告的局限性。方法研究对象为拟诊首次急性心肌梗塞发病后4小时内入院的病人,年龄21至70岁,男女不论。有心动过缓(慢于50次/分)、低血压(收缩压低于100毫米汞柱)、显著的左心衰竭的临床证据、房室传导阻滞、急性心肌梗
In this paper, a randomized double-blind multicenter study of patients with suspected acute myocardial infarction (AMI) who received intravenous beta-blocker timolol or placebo within 5 hours of onset of symptoms was performed. In this paper, cumulative creatine phosphokinase release index and continuous cardiac vector plot analysis of the method to measure the extent of myocardial damage in order to overcome the limitations of some previous reports. Methods Patients were admitted to hospital within 4 hours after the first diagnosis of acute myocardial infarction. They were 21 to 70 years old, regardless of gender. There are bradycardia (slower than 50 beats / min), hypotension (systolic blood pressure below 100 mmHg), clinical evidence of significant left heart failure, atrioventricular block, acute myocardial infarction