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目的研究一氧化氮(NO)在小肠消化间期移行性复合运动(MMC)控制中的作用。方法在大鼠十二指肠、空肠分别埋置应变片,在动物清醒的状态下分别记录空腹和餐后静脉输注NG硝基L精氨酸甲酯(LNAME)、L精氨酸、D精氨酸、硝普钠和血管紧张素Ⅰ后十二指肠和空肠压力变化。结果在餐后注入一氧化氮合酶抑制剂LNAME,可诱发类似空腹状态下的MMC运动形式;注入NO供体硝普钠,则中断空腹时的小肠MMC周期,诱发进食后小肠运动形式;L精氨酸和LNAME同时输注,消除LNAME的作用,而D精氨酸无此作用。单独输注L精氨酸、D精氨酸或血管紧张素Ⅰ对小肠MMC没有影响。结论小肠神经系统NO紧张性分泌的调节,可能与小肠消化间期和消化期之间小肠运动形式的转换有关,NO释放增加可导致Ⅱ相时间变长,中断或延长MMC;抑制NO合成与小肠消化间期运动形式的产生有关。
Objective To study the role of nitric oxide (NO) in the control of small intestine interdynamic transitional motility (MMC). Methods Strain gauges were embedded in the duodenum and jejunum of rats respectively. Fasting and postprandial venous infusion of NG-L-arginine methyl ester (L-NAME), L Arginine, D-arginine, sodium nitroprusside and angiotensin I after duodenum and jejunal pressure changes. Results in the postprandial nitric oxide synthase inhibitor L NAME induced similar to the form of MMC in fasting state of motion; injection of NO donor sodium nitroprusside, the interruption of fasting small intestine MMC cycle induced small intestine after eating form of movement ; L arginine and L-NAME simultaneous infusion, eliminating the role of L NAME, and D arginine no such effect. L-arginine infusion alone, D-arginine or angiotensin I had no effect on the small intestine MMC. Conclusion The regulation of NO secretion in the small intestine may be related to the change of small intestine during the process of intestine digestion and small intestine. Increased NO release may lead to prolonged phase Ⅱ, interruption or prolongation of MMC, inhibition of NO synthesis and small intestine Intermittent movement of the generation of forms related.