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目的研究2型糖尿病患者中载脂蛋白M(apolipoprote in M,apoM)与脂蛋白及其他载脂蛋白的相关关系。方法用dot-b lotting法检测73例2型糖尿病患者(36男37女)血浆中apoM的水平,酶法及比浊法检测糖尿病患者血浆中载脂蛋白AI(apoAI)、载脂蛋白B(apoB)、脂蛋白a[Lp(a)]、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)以及空腹血糖(G lu),ELISA法测定血浆中瘦素的含量,对apoM与其它脂蛋白、载脂蛋白、瘦素的关系作相关性分析。结果男性病例中,apoM负相关于甘油三酯(r=-0.364 8,P=0.028 7),但与年龄成正相关(r=0.375 2,P=0.026 4)。女性病例中apoM负相关于血浆Lp(a)水平(r=-0.442 0,P=0.007 0),正相关于apoAI/apoB(r=0.458 3,P=0.004 3)。男女病例混合分析发现,apoM负相关于Lp(a)(r=-0.338 5,P=0.003 0),正相关于apoAI(r=0.232 1,P=0.046 6)、瘦素(r=0.247 1,P=0.032 6)和年龄(r=0.242 0,P=0.035 2)。结论apoM负相关于Lp(a),正相关于apoAI、apoAI/apoB,提示了apoM可能是抑制动脉粥样硬化的保护因子。如果体内apoM与apoAI同时升高,可能会降低体内Lp(a)水平。
Objective To investigate the relationship between apolipoprotein M (apoM) and lipoproteins and other apolipoproteins in type 2 diabetic patients. Methods The levels of apoM in 73 patients with type 2 diabetes mellitus (36 males, 37 females) were detected by dot-b lotting method. The levels of apoAI, apolipoprotein B apoB, lipoprotein a, triglyceride, HDL-C, LDL-C and G lu, ELISA Determination of plasma leptin content, apoM and other lipoprotein, apolipoprotein, leptin correlation analysis. Results In male patients, apoM negatively correlated with triglyceride (r = -0.364 8, P = 0.028 7), but positively correlated with age (r = 0.375 2, P = 0.026 4). In women, apoM negatively correlated with plasma Lp (a) levels (r = -0.442 0, P = 0.007 0) and positive correlation with apoAI / apoB (r = 0.458 3, P = 0.004 3). Mixed analysis of male and female cases showed that apoM negatively correlated with Lp (a) (r = -0.338 5, P = 0.003 0), positively correlated with apoAI (r = 0.232 1, P = 0.046 6) , P = 0.032 6) and age (r = 0.242 0, P = 0.035 2). Conclusions ApoM is negatively related to Lp (a) and positive to apoAI and apoAI / apoB, suggesting that apoM may be a protective factor against atherosclerosis. If both apoM and apoAI increase in vivo at the same time, it may reduce the level of Lp (a) in vivo.