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在抑制肝癌发生的动物长期实验基础上，建立抑制致肝癌作用的大鼠短期实验模型，筛选研究对黄曲霉毒素（ＡＦＢ１）和（或）二乙基亚硝胺（ＤＥＮ）致肝癌有抑制作用的天然物和中药。发现有化学预防作用的抑制物及其抑制率为：绿茶叶（６９．０７％）及其水醇提取物（５９．５７％－６９．１５％），茶多酚（６５．７３％），咖啡（８６．８４％）．香菇（４２．２４％），猴头菇（３１．０６％），菊花（４２．１２％），银花（４１．１１％），当归（９３．６５％）。丹参（８４．２１％），五味子（９５．５２％）及其制剂联苯双酯（４８．８４％），甘草（５５．３６％）及其制剂甘草甜素（４６．７４％），柴胡（５２．８６％），白芨（４５．６１％），土茯苓（４０．８２％），番桃叶（４０．０３％），橘皮提取物（３７．１２％）．绞股蓝总苷（３１．８７％）和左旋咪唑（５４．３５％）等。经肝癌高发区高危人群预防试验，绿茶、丹参和左旋咪唑等均可降低肝癌发生率，其保护率分别为６７．１８％，４９．６０％和７３．３４％。
On the basis of long-term experiments for the inhibition of hepatocarcinogenesis, a short-term experimental model for the inhibition of hepatocarcinogenesis was established. Screening studies were conducted to inhibit hepatoma caused by aflatoxin (AFB1) and diethylnitrosamine (DEN). Natural products and herbs. Inhibitors found to have chemopreventive effects and their inhibition rates were: green tea leaves (69.07%) and their hydroalcoholic extracts (59.57%-69.15%), tea polyphenols (65.73%), Coffee (86.84%). Mushrooms (42.24%), Hericium erinaceus (31.06%), Chrysanthemum (42.12%), Silver flower (41.11%), Angelica (93.65%). Salvia miltiorrhiza (84.21%), schisandra (95.52%) and its preparations biphenyl diester (48.84%), licorice (55.36%) and its preparation glycyrrhizin (46.74%), firewood Hu (52.86%), white peony (45.61%), soil peony (40.82%), fan peach leaf (40.03%), orange peel extract (37.12%). Gynostemma glycosides (31.87%) and levamisole (54.35%). In the high-risk population prevention trials in high-risk areas of liver cancer, green tea, salvia miltiorrhiza and levamisole can all reduce the incidence of liver cancer, and the protection rates are 67.18%, 49.60% and 73.34%, respectively.