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药典规定草乌的炮制方法用清水制。本文作者用高压蒸制法代替清水制法。经LD50测定和离体蛙心试验证明,二种炮制方法和生草乌比均能降低毒性。从镇痛试验和Vit C含量测定证明,二种炮制方法和生草乌比均能保持疗效。二种不同炮制方法不论在毒性或在疗效方面差别不大,且用薄层层折法比较,二者化学成分是相同的。但高压法较药典法却有总生物碱含量高,原药材损失少,方法简便,周期缩短,节约大量人力物力的优点。因此认为高压法完全可以代替药典法。
The pharmacopoeia stipulates that the processing method of Aconitum is made of clear water. The author of this article uses high-pressure steaming instead of clear water. As demonstrated by LD50 assay and ex vivo frog heart tests, both methods of preparation and Sapbux can reduce toxicity. From the analgesic test and the determination of Vit C content, it was proved that both methods of concoction and Sapbux can maintain curative effect. Two kinds of different processing methods have no significant difference in toxicity or efficacy, and the chemical composition of the two is the same, compared with the thin layer layer folding method. However, compared with the pharmacopoeia method, the high pressure method has a higher content of total alkaloids, less loss of the original medicinal materials, a simple method, a shorter cycle, and saves a lot of manpower and material advantages. Therefore, it is considered that the high pressure method can completely replace the pharmacopoeia law.