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目的探讨血清胱抑素C、血清肌酐和尿β2-微球蛋白检测对高尿酸血症肾损害早期诊断的临床价值,为高尿酸血症肾损害的早期诊断提供有效的科学依据。方法选取解放军总医院2009年9月～2012年1月收治的符合原发性高尿酸血症诊断标准的患者74例作为观察组,同时选取具有可比性的健康人员74例作为对照组,检测两组人员的血清胱抑素C、血清肌酐和尿β2-微球蛋白,并进行比较分析。结果观察组血清胱抑素C[(1.1±0.3)mg/L]、血清肌酐[(98.6±14.5)μmol/L]、尿β2-微球蛋白[(0.2±0.1)mg/L]均明显高于对照组血清胱抑素C[(0.6±0.2)mg/L]、血清肌酐[(84.1±12.9)μmol/L]、尿β2-微球蛋白[(0.1±0.0)mg/L],差异有统计学意义(P<0.05或P<0.01)。观察组血清胱抑素C、血清肌酐、尿β2-微球蛋白各指标间具有一定的相关性。结论血清胱抑素C、血清肌酐和尿β2-微球蛋白检测均能不同程度反映高尿酸血症患者肾小球滤过功能的损害状况,三种检测方法均可作为高尿酸血症肾损害早期诊断的敏感指标。血清胱抑素C、血清肌酐和尿β2-微球蛋白检测用于早期诊断高尿酸血症肾损害是安全有效的检测方法,值得临床推广使用。
Objective To investigate the clinical value of serum cystatin C, serum creatinine and urinary β2-microglobulin in the early diagnosis of hyperuricemia and renal damage, and to provide an effective scientific basis for the early diagnosis of hyperuricemia and renal damage. Methods Seventy-four patients who met the diagnostic criteria of primary hyperuricemia admitted to PLA General Hospital from September 2009 to January 2012 were selected as the observation group. Meanwhile, 74 healthy volunteers were selected as the control group, Serum cystatin C, serum creatinine and urinary β2-microglobulin in group were compared and analyzed. Results Serum levels of cystatin C [(1.1 ± 0.3) mg / L], serum creatinine [(98.6 ± 14.5) μmol / L] and urinary β2- microglobulin [(0.2 ± 0.1) mg / L] Serum creatinine [(84.1 ± 12.9) μmol / L] and urinary β2-microglobulin [(0.1 ± 0.0) mg / L] were significantly higher than those in the control group The difference was statistically significant (P <0.05 or P <0.01). Observation group serum cystatin C, serum creatinine, urinary β2-microglobulin index between a certain correlation. Conclusion Serum levels of cystatin C, serum creatinine and urinary β2-microglobulin can all reflect the extent of glomerular filtration dysfunction in patients with hyperuricemia to varying degrees. All three methods can be used as a marker of hyperuricemia and renal damage Early diagnosis of sensitive indicators. Serum cystatin C, serum creatinine and urinary β2-microglobulin test for the early diagnosis of hyperuricemic renal damage is a safe and effective detection method, worthy of clinical promotion and use.