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目的通过探讨氨基胍(AG)对早期糖尿病(DM)大鼠一氧化氮(NO)、一氧化氮合酶(ni-tric oxi desynthase,NOS)活性及24h尿蛋白排泄量(24hUPE)的影响,了解氨基胍对糖尿病肾病的治疗作用。方法健康清洁级Wistar大鼠40只,检测24hUPE、血清NO水平、总一氧化氮合酶(total nitric oxide synthase,tNOS)和诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)及结构型一氧化氮合酶(constructive nitric oxide synthase,cNOS)活性等5项指标后,用链脲佐菌素(Streptozotocin,STZ)60mg/kg制备成糖尿病大鼠模型,将糖尿病鼠随机分为糖尿病对照组、氨基胍组(AG组)。于8周末时再检测大鼠的上述5项指标并进行统计分析。结果①与造模前比较,DM对照组在8周末时24hUPE、NO和iNOS升高(P<0.01,P<0.05);AG组24hUPE增加(P<0.01),tNOS、iNOS、cNOS降低(P<0.01,P<0.05)。②与DM对照组比较,8周末时AG组5项指标均下降(P<0.05)。结论在糖尿病肾病(DN)的发展进程中,早期阶段应用AG可通过降低血NOS活性、NO生成量及其他机制,使24hUPE减少,减轻肾脏的损害。
Objective To investigate the effect of aminoguanidine (AG) on the activity of nitric oxide (NO), nitric oxide synthase (NOS) and urinary protein excretion (24hUPE) in early stage of diabetic rats, Understand the role of aminoguanidine in the treatment of diabetic nephropathy. Methods Forty healthy Wistar rats were examined for 24hUPE, serum NO level, total nitric oxide synthase (tNOS), inducible nitric oxide synthase (iNOS) and structure type After 5 indexes of nitric oxide synthase (cNOS) activity and so on, diabetic rat model was made by using 60 mg / kg streptozotocin (STZ). The diabetic rats were randomly divided into diabetic control group , Aminoguanidine group (AG group). At the end of the 8th week, the above five indexes of rats were further tested and statistically analyzed. Results (1) Compared with those before modeling, 24hUPE, NO and iNOS in DM control group increased at the end of 8th week (P <0.01, P <0.05); 24hUPE increased in AG group (P <0.01), while tNOS, iNOS and cNOS decreased <0.01, P <0.05). ② Compared with DM control group, all the 5 indexes of AG group decreased at the end of the 8th week (P <0.05). Conclusions In the development of diabetic nephropathy (DN), AG at early stage can reduce 24hUPE and reduce renal damage by decreasing blood NOS activity, NO production and other mechanisms.