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[目的]探讨卵巢上皮性癌在手术、化疗及热疗等综合治疗中,临床分期、术后残留癌灶大小、术后化疗及热疗因素与生存率的关系。[方法]回顾分析 1990年元月至 1995年 12月 6年间收治的卵巢上皮性癌 89例的临床资料。其中 I期 19例, Ⅱ期21例,Ⅲ期49例。 28例行全子宫,双侧附件, 阑尾、大网膜切除。其中21例行盆腔淋巴结切除, 5例行单侧附件切除,6例行部分卵巢切除及盆腔肿瘤组织活检,术后54例行常规化疗,采用PAC方案,30例加用热疗。[结果]5年生存率为Ⅰ期78.94%,Ⅱ期47.62%,Ⅲ期18.37%。术后无残留癌灶5年生存率为44.74%,≥2cm者5年生存率为0;术后常规化疗8~10个疗程5年生存率为57.41%;未化疗者为8.57%;化疗后加热疗5年生存率为73.33%,未加热疗者为21.43%(P<0.05)。[结论]临床分期愈早,手术后无或残留癌灶< 2cm,常规化疗 8~ 10个疗程以及加热疗者疗效较好。
[Objective] To investigate the clinical staging, the size of residual tumor, the postoperative chemotherapy and hyperthermia factors and the survival rate in ovarian epithelial carcinoma in the comprehensive treatment of surgery, chemotherapy and hyperthermia. [Methods] The clinical data of 89 patients with ovarian epithelial carcinoma admitted from January 1990 to December 1995 were retrospectively analyzed. Of which 19 cases of stage I, 21 cases of stage Ⅱ, 49 cases of stage Ⅲ. 28 routine hysterectomy, bilateral attachment, appendix, omental resection. Among them, pelvic lymph node dissection was performed in 21 cases, unilateral excision in 5 cases, partial ovariectomy and pelvic tumor biopsy in 6 cases. Conventional chemotherapy was performed in 54 cases after operation, with PAC regimen and 30 cases with hyperthermia. [Results] The 5-year survival rate was 78.94% in stage Ⅰ, 47.62% in stage Ⅱ and 18.37% in stage Ⅲ. The 5-year survival rate of non-residual cancer after operation was 44.74%, and the 5-year survival rate of ≥2cm was 0. The 5-year survival rate of 8 ~ 10 cycles of conventional chemotherapy was 57.41% .57%. The 5-year survival rate after radiotherapy was 73.33% and 21.43% before radiotherapy (P <0.05). [Conclusion] The earlier the clinical stage, no or residual cancer after surgery <2cm, conventional chemotherapy for 8 to 10 courses and the heating effect is better.