多腺体自身免疫综合征(Polyglandu-lar Autoimmune Syndrome 下称 PGAS)是由于自身免疫反应引起多腺体衰竭的一疾病组,本病罕见。病例报告:283336号。女性,30岁,1985年10月30日入院。自诉从1967年起周身麻木,蚁走感,间断发生手足搐搦。严重时有恐惧感,时而有不省人事,口吐白沫,但无大小便失禁。七个月后发现全身皮肤逐渐变黑。1983年秋出现心悸、多汗,喜冷怕热,易激动及食量增加。于1984年经抗甲状腺药物治疗症状减轻。查体:全身皮肤粘膜色素沉着,尤以齿龈、乳晕、掌纹、肘膝关 Polyglandu-lar Autoimmune Syndrome (PGAS) is a group of diseases that cause polyglandular failure due to autoimmune reactions. This disease is rare. Case Report: No. 283336 Female, 30 years old, admitted to hospital on October 30, 1985. Private prosecution since 1967 numbness, ants walking sense, intermittent tetany. Seriously when there is fear, sometimes unconscious, foaming at the mouth, but no incontinence. Seven months later found that the body’s skin gradually black. The fall of 1983 palpitations, sweating, like cold afraid of heat, irritability and food intake. In 1984, anti-thyroid drugs to alleviate the symptoms. Physical examination: systemic skin mucosal pigmentation, especially in the gums, areola, palmprint, elbow knee off