论文部分内容阅读
目的:探讨赠卵体外受精-胚胎移植(IVF-ET)供受双方的治疗结局和影响因素。方法:回顾分析2005年4月至2009年12月在河北医科大学第二医院生殖中心行IVF-ET并自愿捐卵的17例供卵患者及同期接受赠卵的16例受卵患者,共19周期的临床资料。供卵组(17例)采用控制性超排卵行IVF-ET;受卵组(16例)采用自然周期或激素替代治疗准备子宫内膜,并分析供、受双方的受精率、妊娠率和种植率。结果:16例患者19周期共接受赠卵108枚,平均每周期接受卵子(5.68±0.82)枚,21个解冻移植周期,8周期妊娠,周期妊娠率为38.1%,累计妊娠率50.0%。供卵的17例患者,10个新鲜胚胎移植周期,2周期妊娠;19个解冻胚胎移植周期,12周期妊娠,冷冻移植周期的妊娠率为63.16%,累计妊娠率64.71%。供、受双方受精率、冷冻胚胎移植周期的妊娠率、累积妊娠率均无统计学差异(P>0.05)。结论:受卵IVF-ET是治疗卵巢功能不良等不能生育健康后代妇女的有效方法;自然周期、激素替代周期可使种植率和临床妊娠率可以达到良好的结局;供卵者提供6个左右的卵子既不影响供卵者的妊娠,也能为受卵者提供一个良好的妊娠机会。
Objective: To investigate the therapeutic outcomes and influencing factors of IVF-ET for both sides. Methods: A retrospective analysis of 17 patients with IVF-ET who had voluntarily donated eggs at the Reproductive Center of the Second Hospital of Hebei Medical University from April 2005 to December 2009 and 16 eggs who received donated eggs during the same period Cycle of clinical data. The ovulation group (17 cases) received controlled ovarian hyperstimulation (IVF-ET). The ovariectomized group (16 cases) received natural cycle or hormone replacement therapy to prepare the endometrium. The fertilization rate, pregnancy rate and implantation rate rate. Results: A total of 108 donated eggs were obtained in 19 patients during the period of 19 cycles. The average number of eggs per cycle was (5.68 ± 0.82), 21 thawed and 8 cycles. The pregnancy rate was 38.1% and the cumulative pregnancy rate was 50.0%. 17 cases of ovulation, 10 fresh embryo transfer cycles and 2 cycles of pregnancy. The pregnancy rate of 19 thawed embryos, 12 cycles of pregnancy and frozen transplant cycles was 63.16%, and the cumulative pregnancy rate was 64.71%. There was no significant difference in fertilization rate, pregnancy rate of frozen embryo transfer cycle and cumulative pregnancy rate (P> 0.05). Conclusion: Ovovariate IVF-ET is an effective method to treat ovarian dysfunction and other offspring that can not give birth to healthy offspring. The natural cycle and hormone replacement cycle can achieve a good outcome in terms of implantation rate and clinical pregnancy rate. Ovovsters provide around 6 Eggs neither affect the pregnancy of the donor, but also provide a good chance of pregnancy for the recipient.