低浓度的稀土化合物水溶液,在1947年就已知具有杀菌作用,1976年Monafo首先提出硝酸铈作为烧伤创面的局部化学治疗药物以取代硝酸银,认为对革兰氏阴、阳细菌都有较强的杀灭作用,尤其对革兰氏阴性肠杆菌属效果更好。1977年Fox提出应用2.2％硝酸铈和1％磺胺嘧啶银,再配以基质制成乳膏,作为烧伤创面的外用 A low concentration aqueous solution of a rare earth compound, known to have bactericidal activity in 1947, was first proposed by Monafo in 1976 as a topical chemotherapeutic agent for burn wounds to replace silver nitrate, which was considered to be superior to both Gram negative and positive bacteria Of the killing effect, especially for Gram-negative Enterobacter effect better. In 1977, Fox proposed the use of 2.2% cerium nitrate and 1% sulfadiazine silver, together with the matrix made of cream, as a burn wound topical