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本文报告了重组人内皮细胞衍生白细胞介素－８（ｒＥＤｈＩＬ－８）对大鼠失血性休克的作用，并对其抗休克机制作初步探讨。大鼠股动脉快速放血至平均动脉血压５．３２ｋＰａ，维持９０ｍｉｎ，复制晚期失血性休克模型。结果发现ｒＥＤｈＩＬ－８（２５０μｇ／ｋｇ，ｉ．ｗ．）能够明显提升晚期失血性休克大鼠的平均动脉血压，改善休克状态，提高存活率，休克晚期血浆内皮素（ＥＴ）浓度显著升高，给予ｒＥＤｈＩＬ－８后，在休克状态改善的同时，血浆ＥＴ浓度也明显降低，并且显著低于休克对照组大鼠血浆ＥＴ浓度。结果表明ｒＥＤｈＩＬ－８具有很强的抗休克作用，并提示ｒＥＤｈＩＬ－８的抗休克作用与其抑制ＥＴ的产生和保护血管内皮有关。
This article reports the effect of recombinant human endothelial cell-derived interleukin-8 (rEDhIL-8) on hemorrhagic shock in rats and its anti-shock mechanism. Rat femoral artery rapid bleeding to an average arterial pressure of 5.32kPa, maintaining 90min, replication of advanced hemorrhagic shock model. The results showed that rEDhIL-8 (250μg / kg, i.w.) could significantly increase the mean arterial blood pressure, improve the state of shock and improve the survival rate of rats with advanced hemorrhagic shock. The plasma endothelin (ET) After administration of rEDhIL-8, the plasma ET concentration was significantly decreased at the same time as the shock status was improved, and was significantly lower than that of the shock control group. The results showed that rEDhIL-8 has a strong anti-shock effect, and prompted rEDhIL-8 anti-shock and its inhibition of ET production and protection of the vascular endothelial.