目的　探讨系统性红斑狼疮 (SLE)累积器官损害的规律及其影响因素。方法　对 162份SLE病历资料进行回顾性分析 ,采用SICC/ACR损害指数评估其累积器官损害并分析评价其影响因素。结果　累积器官损害同首诊时间、合用环磷酰胺冲击治疗、复发次数及补体水平呈显著性相关 ;而与性别、年龄、病程及皮质类固醇激素累积剂量无显著性相关。结论　累积器官损害是评价SLE病情的指标之一 ,其发生、发展受多因素相互作用。应早期治疗并连续观察实验室指标尤其是血清补体水平 ,激素治疗的同时若合用大剂量环磷酰胺冲击可延缓器官发展至终末期损害 Objective To investigate the regularity and influencing factors of organ damage in systemic lupus erythematosus (SLE). Methods The data of 162 SLE cases were retrospectively analyzed. The cumulative organ damage was evaluated by SICC / ACR damage index and the influencing factors were analyzed. Results The accumulative organ damage was significantly correlated with the time of initial diagnosis, the combination of cyclophosphamide, the frequency of relapse and the level of complement, but not with the gender, age, duration of disease and the cumulative dose of corticosteroids. Conclusion Accumulation of organ damage is one of the indicators to evaluate the condition of SLE. The occurrence and development of it are influenced by many factors. Should be treated early and continuous observation of laboratory indicators, especially serum complement levels, while hormone therapy combined with high doses of cyclophosphamide can delay organ development to end-stage damage