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目的 动态观察人类母乳中胰岛素样生长因子 1(IGF 1)在初乳及成熟乳中的变化及其与泌乳量的关系 ;探讨母乳中IGF 1水平对新生儿生长发育的影响。方法 监测 38名足月新生儿生后 6周身长、体重、头围的增长及其母亲体重指数。采用双抗放射免疫法测定初乳 (生后 3～ 5d)和成熟乳 (生后 4 2d)中IGF 1的浓度并测量同日母乳量 ,测量新生儿生后 3～ 5d血清IGF 1浓度 ,并分析两者之间的关系。结果 (1)初乳中IGF 1浓度 [(6 3± 1 6 ) μg/L]显著高于成熟乳 [(4 7± 2 1) μg/L],差异有显著意义 (t=3 2 32 ,P <0 0 5 )。 (2 )初乳和成熟乳中IGF 1的浓度 [分别为 (6 3± 1 6 ) μg/L ,(4 7± 2 1) μg/L]均与同日母乳分泌量 [分别为 (380± 114 )ml/d ,(783± 199)ml/d]呈正相关 (r分别为 0 6 17,0 793) ;乳量绝对不足的母亲初乳中IGF 1浓度 [(4 1± 1 5 ) μg/L]明显低于能维持母乳喂养者 [(6 3± 1 6 ) μg/L],差异有显著意义 (t=4 4 5 4 ,P <0 0 0 1)。 (3)与新生儿体重、头围增长相关的因素按相关性大小依次为成熟乳量、初乳中IGF 1的浓度、新生儿生后早期血清IGF 1水平以及母亲哺乳期的体重指数。结论 初乳中足够的IGF 1浓度是启动泌乳并使之得以维持的重要条件 ,乳腺分泌的IGF 1可能通过促进?
Objective To observe dynamically the changes of human insulin 1 (IGF 1) in colostrum and mature milk and its relationship with milk production, and to explore the effect of IGF 1 in breast milk on the growth and development of newborns. Methods The body length, body weight, head circumference and body mass index of 38 full-term newborns at 6 weeks after birth were monitored. The concentration of IGF-1 in colostrum (3 ~ 5 days after birth) and mature milk (42 days after birth) was measured by double-antibody radioimmunoassay and the same amount of breast milk was measured. The serum IGF-1 level was measured 3 ~ 5 days after birth Analyze the relationship between the two. Results (1) The concentration of IGF1 in colostrum [(6 3 ± 1 6) μg / L] was significantly higher than that in mature milk [(47 ± 2 1) μg / L] , P <0 0 5). (2) The concentrations of IGF1 in colostrum and mature milk [(6 3 ± 1 6) μg / L, (47 ± 2 1) μg / L, respectively] 114) ml / d, (783 ± 199) ml / d] (r = 0, 6 and 17,0793, respectively) / L] was significantly lower than those who could maintain breastfeeding [(6 3 ± 1 6) μg / L], the difference was significant (t = 4454, P <0.01). (3) The factors associated with the growth of body weight and head circumference of newborns were related to the amount of mature milk, the concentration of IGF-1 in colostrum, the serum IGF-1 level in newborns and the body mass index of lactation mothers. CONCLUSION Adequate concentrations of IGF1 in colostrum are important conditions for initiating and maintaining lactation, and IGF1 secreted by mammary glands may promote