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目的：研究表皮生长因子受体（ＥＧＦＲ）在胃癌中的表达及其临床意义。方法：应用免疫组化技术（ＡＢＣ法），对９４例胃癌及癌旁组织中ＥＧＦＲ的表达进行半定量检测，观察其同胃癌临床病理参数及预后的关系。结果：（１）ＥＧＦＲ在正常胃粘膜中无表达，而在胃癌中的表达率为４０４％，癌旁组织及新生血管中ＥＧＦＲ有阳性表达；（２）ＥＧＦＲ的表达与患者的性别、年龄和肿瘤大小无关（Ｐ＞０．０５），而与肿瘤的生长方式、浆膜层受浸与否、分化程度、有无淋巴结转移和临床分期关系密切（Ｐ＜０．０５）。（３）ＥＧＦＲ表达与患者的生存期密切相关（Ｐ＜０．０１），ＥＧＦＲ阳性者预后差，阴性者预后好。结论：ＥＧＦＲ检测可作为判定胃癌生物学行为和预后的一项良好指标
Objective: To study the expression and clinical significance of epidermal growth factor receptor (EGFR) in gastric cancer. METHODS: Immunohistochemical technique (ABC method) was used to semi-quantitatively measure the expression of EGFR in 94 cases of gastric cancer and paracancerous tissues, and to observe its relationship with clinicopathological parameters and prognosis of gastric cancer. Results: (1) EGFR was not expressed in normal gastric mucosa, but its expression rate was 40.4% in gastric cancer. Positive expression of EGFR was found in para-cancer tissue and neovascularization. (2) Expression of EGFR and patient gender, Age was not related to the size of the tumor (P>0.05), but was closely related to the growth pattern of the tumor, whether the serosal layer was immersed or not, the degree of differentiation, lymph node metastasis, and clinical stage (P<0.05). (3) The expression of EGFR was closely related to the survival period of patients (P<0.01). The prognosis of patients with positive EGFR was poor, and the prognosis of patients with negative EGFR was good. Conclusion: EGFR detection can be used as a good indicator to determine the biological behavior and prognosis of gastric cancer