目的综述了水飞蓟宾预防和治疗前列腺癌的作用机制。方法对近几年国内外文献资料进行总结和归纳。结果水飞蓟宾是水飞蓟种子提取物水飞蓟素的主要有效成分,它可以通过改变细胞周期进程,抑制有丝分裂和细胞存活信号、抑制肿瘤细胞血管生成因子的分泌、以及促使上皮细胞凋亡等方式来抑制前列腺癌细胞的分化和生长。而且水飞蓟宾对化疗药物阿霉素表现协同作用,可以缓和前列腺特异抗原的升高。结论由于水飞蓟宾几乎没有毒性,现已被用作食品添加剂以预防前列腺癌。它也已进入临床试验,可望在不久的将来成为防治前列腺癌的药品。 Objective To summarize the mechanism of silybin in the prevention and treatment of prostate cancer. Methods To summarize and summarize the literatures at home and abroad in recent years. Results Silybin was the main active ingredient of the silymarin seed extract. It could change the cell cycle process, inhibit the signal of mitosis and cell survival, inhibit the secretion of angiogenic factor in tumor cells, and promote the apoptosis of epithelial cells To inhibit the differentiation and growth of prostate cancer cells. And silybin on the chemotherapeutic drug doxorubicin synergy, can alleviate the prostate-specific antigen. Conclusion Silybin has been used as a food additive to prevent prostate cancer since it is almost non-toxic. It has also entered clinical trials and is expected to become a drug against prostate cancer in the near future.